We recommend using a protective water resistant mattress cover on your new 4Sleep mattress. In the event something does get spilled on the mattress, try to spot clean by hand (do not rub). If that doesn’t take care of it, you can remove the cover and machine wash it in cold water only! Beware! No hot water, No dryer, No iron and No dry clean. Sounds like a lot of No’s but the 4Sleep cover has very special properties and should be treated that way.